Novel Targets in Drug Discovery: Industry Research Report

Novel Targets in Drug Discovery

Published Date: November 2006

Published By: Drug and Market Development Publishing

Page Count: 163

Order Code: R294-222

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EXECUTIVE SUMMARY
CHAPTER 1: HISTORICAL PERSPECTIVE
CHAPTER 2: DRUG DISCOVERY IN THE LATE TWENTIETH CENTURY: The Basis of Inheritance; The Genetic Code; Biotechnology; The Human Genome Project; Functional Genomics; Target Identification; Target Validation; Lead Discovery; Lead Optimization; Proteomics; Preclinical Development; Clinical Development
CHAPTER 3: DRUG DISCOVERY IN THE POST-GENOMIC ERA: ‘Traditional’ Drug Discovery; The Promise of Genomics; Reductionism Criticized; Target Identification; Discovery Screens; How Many Targets?; The Importance of Druggability
CHAPTER 4: THE NATURE OF DRUG TARGETS: Enzymes; Ion channels; Receptors; Hormones and Factors; Recent Novel Drug Targets
CHAPTER 5: CONCLUSIONS
CHAPTER 6: COMPANY PROFILES: Aerovance; Alliance Pharmaceutical; Cara Therapeutics; deCODE Genetics; Elbion; Genfit; Nutra Pharma; Prestwick Pharmaceuticals; Solbec Pharmaceuticals; Somaxon; Trion Pharma
APPENDIX 1: DRUGGABILITY STUDIES: Other Approaches
APPENDIX 2: RECEPTOR FAMILIES: Receptor Families
APPENDIX 3: REFERENCES
TABLE OF EXHIBITS: Exhibit 1.1 Traditional Routes of New Drug Discovery; Exhibit 1.2 Examples of Ligands Using Various Second Messenger Systems; Exhibit 1.3 cAMP as a Second Messenger; Exhibit 2.1 Composition of Nucleic Acids; Exhibit 2.2 Gene Expression; Exhibit 2.3 The Central Dogma of Biology; Exhibit 2.4 What Sequencing the Human Genome Does Not Reveal; Exhibit 2.5 The Drug Discovery Process; Exhibit 3.1 Blockbusters whose Success was not Anticipated at the Time of Selection; Exhibit 3.2 The Biochemical Classes of Therapeutic Drug Targets; Exhibit 3.3 Number of Potential Drug Targets; Exhibit 4.1 Typical Concentrations of Ions Inside and Outside the Cell; Exhibit 4.2 Hormones and Factors used as Drug Targets; Exhibit 4.3 Distribution of Novel Drug Targets (2004 - 2006); Exhibit 4.4 Novel Targets under Development (January 2004 to November 2006); Exhibit 4.5 High Potential Drug Development Projects; Exhibit 4.6 High Potential Development Projects involving Novel Targets; Exhibit 4.7 Target Involvement of High Potential Projects; Exhibit 4.8 Large Company Target Involvement; Exhibit 5.1 Total Market Size Distribution; Exhibit App2.1 Pharmaceutical Research Involving Dopamine Receptors; Exhibit App2.2 Classification of 5-HT Receptors