• Scope and Methodology
• Challenges Facing the Pharmaceutical Industry
  • Meeting Investor Expectations
  • Erosion of Blockbuster Sales
  • Increased Generic Competition
  • Pricing Pressures
  • Pipeline Output Slowing Compared to ROI
  
  
• Strategies to Address Challenges
  • Mergers and Acquisitions
  • Strategic Outsourcing
  • Outsourcing Manufacturing Operations
  • Outsourcing Sales Force
  
  
• Contract Manufacturing
  • Biopharmaceutical Manufacturing
  • Characteristics of Biopharmaceutical Manufacturing
  • Biopharmaceutical Manufacturing Demand Increasing
  • CMOs Expanding Operations to Manufacture Biologics
  
  
• Contract Primary Manufacturing
  • Ramping up the Technology Toolbox to Gain a Competitive Edge
  
  
• Secondary Sterile Contract Manufacturing
  • Demand for Sterile Manufacturing Capabilities on Increase
  
  
• Market Analysis: Contract Manufacturing
• Contract Sales and Marketing
  • Contract Sales Organizations
  • Governmental and Organizational Regulations
  • Drivers of Outsourcing Sales & Marketing
  • CSOs’ Broad-Based Portfolio of Marketing and Sales Services
  • Maximizing Rate of Investment
  • Services Offered by CSOs
  • Market Analysis: Contract Sales and Marketing

Chapter Two: Meeting the Challenges of a Changing Marketplace

• Challenges Facing the Pharmaceutical Industry
  • Meeting Investor Expectations
  • Erosion of Blockbuster Sales
  • Increased Generic Competition
  • Pricing Pressures
  • Pipeline Output Slowing Compared to ROI
  
  
• Strategies to Address Challenges
  • Mergers and Acquisitions
  • Strategic Outsourcing
  • Restructuring Manufacturing Operations
  • Reducing the Size of In-House Sales Force

Chapter Three: Contract Manufacturing

• Industry Overview
• Major Drivers of Contract Manufacturing
• Key Competing Factors for Contract Manufacturers
• Biopharmaceutical Manufacturing
  • Characteristics of Biopharmaceutical Manufacturing
  • Types of Contractors Involved in Biomanufacturing
  • Biopharmaceutical Manufacturing Demand
  • Leading Protein Products and Market Value
  • Production Capacity for Biopharmaceutical Manufacturing
  • Alternative Methods of Producing Biopharmaceuticals
  • First Transgenically Produced Pharmaceutical Recommended for Approval
  • CMOs Expanding Operations to Manufacture Biologics
  • Asian CMOs Entering Biomanufacturing
  
  
• Contract Primary and Secondary Manufacturing
• Contract Primary Manufacturing
  • Ramping up the Technology Toolbox to Gain a Competitive Edge
  • Chiral Technologies
  • Oligonucleotides and Peptides Capabilities
  • Specialized Niches Offer Opportunity
  • Dangerous Reagents
  • Controlled Substances
  • Exploring Other Growth Opportunities
  
  
• Contract Secondary Manufacturing
  • Demand for Sterile Manufacturing Capabilities on Increase
  
  
• Market Analysis: Contract Manufacturing
  • Contract Biomanufacturing
  • Market Size, Growth, and Forecast
  • Contract Biomanufacturing Market Share
  • Contract Sterile Secondary Manufacturing
  • Biologics Drive Special Manufacturing Processes
  • Ramping up Sterile Manufacturing
  • Market Size, Growth, and Forecast
  • Contract Sterile Secondary Manufacturing Market Share
  • Contract Primary Manufacturing
  • Technological Innovations Fend off Sluggish Market
  • Globalization Trend
  • Market Size, Growth, and Forecast
  • Contract Primary Manufacturing Market Share

Chapter Four: Contract Sales and Marketing

• Contract Sales Organizations
• Governmental and Organizational Regulations
  • Prescription Drug Marketing Act (PDMA)
  
  
• Title 21 Code of Federal Regulations, Part 11 (21 CFR Part 11)
• Office of Inspector General Guidelines (OIG) for Industry
  • Health Insurance Portability and Accountability Act (HIPAA)
  • Additional Guidelines Established by Industry and Professional Organizations
  
  
• Drivers of Outsourcing Sales & Marketing
  • Broad-Based Portfolio of Marketing and Sales Services
  • Maximizing Efficiency in Sales and Marketing
  • Speed and Flexibility
  • Provide Sales Team to Companies with No In-House Sales/Marketing Expertise
  
  
• Selecting a CSO
  • Range of Services
  • Integrated Sales Force Recruitment, Training, and Management
  • Implementation Services
  • Technical Support Service
  • Data Center Services
  • Call Center Services
  • Hardware Support Services
  • Training and Educational Services
  • Product, Sample and Literature Fulfillment
  • Telemarketing
  • Brand/Portfolio Analytics and Forecasting
  • Strategic and Tactical Planning
  • Strategic Consulting
  
  
• CSO-Client Contracts
• Improving Sales Force Effectiveness Through Technology-Based Solutions
  • E-detailing
  • Virtual Live e-Detailing
  • Scripted e-Detailing
  • Physician Portal e-Detail
  
  
• Customer Relationship Management
  • Mobile Technology
  • Outsourcing CRM-related Services
  • Information Management
  • Business Intelligence & Analytics
  • Commercial Operations
  
  
• Market analysis: Contract Sales and Marketing
  • Industry Characteristics
  • Market Environment
  • CSO Market and Forecast
  • CSO Market Share
  
  
• Strategies for Gaining Market Share
  • Expanding into China
  • Strategic Acquisitions

Chapter Five: Contract Manufacturing Company Profiles

• Avecia Biotechnology, Inc.
  • History and Lines of Business
  • Contract Manufacturing
  • Manufacturing DNA Medicines
  • Manufacturing Biologics
  
  
• Bachem Holding AG
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Baxter Pharma Solutions
  • History and Lines of Business
  • Contract Manufacturing Services
  • Proprietary Formulation Technologies
  • Financial Information
  
  
• Bayer Pharmaceutical Manufacturing Services
  • History and Lines of Business
  • Contract Manufacturing
  • Financial Information
  
  
• Ben Venue Laboratories
  • History and Lines of Business
  • Contract Manufacturing Services
  • Development Services
  • Clinical Material Manufacturing and Commercial Production
  • International Services
  
  
• Bioreliance Corporation
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Boehringer Ingelheim
  • History and Lines of Business
  • Contract Manufacturing
  • Primary Manufacturing
  • Biopharmaceutical Manufacturing
  • Financial Information
  
  
• Cambrex Corporation
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Cardinal Health
  • History and Lines of Business
  • Contract Manufacturing and Packaging Services
  • Financial Information
  
  
• Chesapeake Biological Laboratories
  • History and Lines of Business
  • Contract Manufacturing Services
  
  
• DPT Laboratories, Ltd.
  • History and Lines of Business
  • Contract Manufacturing Services
  
  
• DSM Pharmaceuticals, Inc.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Degussa AG
  • History and Lines of Business
  • Contract Manufacturing
  • Financial Information
  
  
• Dowpharma
  • History and Lines of Business
  • Contract Manufacturing Services
  • Chiral Products
  • Nucleic Acid Medicines
  • Biopharmaceuticals
  • Plant-Based Production Solution
  • Financial Information
  
  
• Draxis Pharma, Inc.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Genzyme Pharmaceuticals
  • History and Lines of Business
  • Contract Manufacturing Services
  • Equipment
  • Capacity
  • Financial Information
  
  
• Girindus AG
  • History and Lines of Business
  • Contract Manufacturing Services
  
  
• HollisterStier Contract Manufacturing
  • History and Lines of Business
  • Contract Manufacturing Services
  
  
• Hospira, Inc.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Hyaluron, Inc.
  • History and Lines of Business
  • Contract Manufacturing
  
  
• Laureate Pharma
  • History and Lines of Business
  • Contract Manufacturing Services
  
  
• Lonza Group Ltd
  • History and Lines of Business
  • Contract Manufacturing Services: Lonza Biologics
  • Fermentation
  • High Yielding Cell Line
  • Purification
  • Choice of Chromatography Steps
  • Process Scale-Up
  • Process Validation
  • Process Transfer
  • Analytical Services
  • Development of Contaminant Assays
  • Product Characterization
  • Pre-formulation and Stability Studies
  • Analytical Support
  • Molecular Biology
  
  
• Financial Information
• Mallinckrodt Pharmaceuticals Outsourcing
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Patheon, Inc.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
  
  
• Siegfried, Inc.
  • History and Lines of Business
  • Contract Manufacturing
  • Financial Information
  
  
• Wellspring Pharmaceutical
  • History and Lines of Business
  • Contract Manufacturing

Chapter Six: Contract Sales and Marketing Company Profiles

• Cardinal MarketForce
  • History and Lines of Business
  • Contract Sales and Marketing
  • Recruitment
  • Syndicated sales
  • Customer-segment sales
  • Sales force planning
  • Training and development
  • Information management and reporting
  • Strategic Planning
  • Content development
  • Execution and implementation
  • Data collection and information management systems
  • Medical Education Systems
  • Financial Information
  
  
• Dendrite International, Inc.
  • History and Lines of Business
  • Contract Marketing and Sales Support Services
  • Customer Relations Management Solutions:
  • Information Management:
  • Commercial Operations Management:
  • Consumer Goods Software:
  • Implementation Services:
  • Technical and Hardware Support Services:
  • Data Center Services:
  • Call Center Services:
  • Asset Management Services:
  • Sales Force Support Services:
  • Financial Information
  
  
• Innovex, Inc.
  • History and Lines of Business
  • Contract Sales and Marketing Services
  • Financial Information
  
  
• Medical Affairs, Marketing & Communications
  • History and Lines of Business
  • Contract Marketing and Market Research
  • Financial Information
  
  
• inVentiv Health, Inc.
  • History and Lines of Business
  • Contract Sales and Marketing Services
  • inVentiv Clinical
  • inVentiv Communications
  • inVentiv Commercial
  • Financial Information
  
  
• OnCall, LLC
  • History and Lines of Business
  • Contract Sales Services
  • Dedicated Field Sales Teams
  • Shared Field Sales Teams - OnCall-Share
  • Medical Scientific Liaison Services
  • Deployment options
  • Telesales
  • Marketing Services
  
  
• PDI, Inc.
  • History and Lines of Business
  • Contract Sales and Marketing Services
  • Contract Sales
  • Marketing Research
  • Medical Education and Communications
  • Financial Information
  
  
• Vanguard Pharma
  • History and Lines of Business
  • Contract Sales and Marketing
  • National Contract Sales Forces
  • Recruitment and Placement Services
  • New Product Launches Mature Product Support

Appendix: Company Directory

List of Exhibits

Chapter One: Executive Summary

• Figure 1-1: Global Pharmaceutical Sales by Region 2005
• Figure 1-2: Number of Biological Product Clinical Trials in the United States by Development Phase (Phase I through Filing) 2002-2006
• Table 1-1: Selected CMOs Upgrading/Expanding into Sterile Manufacturing, 2002-2006
• Table 1-2: Global Contract Manufacturing Market: Primary, Sterile Secondary, and Biomanufacturing 2001-2011
• Table 1-3: Key Contract Sales Organization Solutions to Maximize ROI
• Table 1-4: Global CSO Market 2001-2011

Chapter Two: Meeting the Challenges of a Changing Marketplace

• Figure 2-1: Global Pharmaceutical Sales by Region 2005
• Table 2-1: Global Research and Development Spending 2000-2010
• Table 2-2: Selected Patent Expirations (Brand, Indication, Manufacturer, 2005 Sales) 2006
• Figure 2-2: Number of NMEs Approved 1994-2004

Chapter Three: Contract Manufacturing

• Table 3-1: Select Contract Manufacturing Subsidiaries of Pharmaceutical and Biotechnology Companies Competing in the Outsourcing Market
• Figure 3-1: Respondents' Areas of Biopharmaceutical Manufacturing Operations: “In which of the following areas does your organization currently have production operations?" [Mammilian Cell Culture, Microbial Fermentation, Yeast, Insect Cells, Plant Cells, Other]
• Figure 3-2: Biotechnology Industry Market Capitalization 1994-2005
• Figure 3-3: Number of Biological Product Clinical Trials in the United States by Development Phase (Phase I through Filing) 2002-2006
• Figure 3-4: Number of NCE Approvals in the United States 1996-2005
• Table 3-2: Selected Protein Therapeutic Sales by Product, 2005
• Table 3-3: Selected Plant-made Biopharmaceuticals in Research and Development
• Table 3-4: Selected Animal-Derived Biopharmaceuticals in Research and Development
• Table 3-5: Selected CMOs Expanding Biomanufacturing Capacity, 2000-2006
• Table 3-6: Selected Established Asian CMOs
• Table 3-7: Selected CMOs Upgrading/Expanding into Sterile Manufacturing, 2002-2006
• Table 3-8: Global Contract Manufacturing Market: Primary, Sterile Secondary and Biomanufacturing 2001-2011 (revenues in $billions)
• Table 3-9: Current Capacity at Key CMOs
• Figure 3-5: Geographic Distribution of Contract Biomanufacturers
• Table 3-10: Global Contract Biomanufacturing Market
• Table 3-11: Contract Biomanufacturing Revenues and Market Share by Leading Supplier 2005
• Table 3-12: Global Contract Sterile Secondary Manufacturing Market 2001-2011
• Table 3-13: Sterile Secondary Manufacturing Revenues and Market Share by Leading Supplier 2005
• Table 3-14: Specific Competitors’ Strategies to Improve Production, Improve Economics, or Expand Capacity
• Table 3-15: Global Contract Primary Manufacturing Market
• Table 3-16: Contract Primary Manufacturers Market Share

Chapter Four: Contract Sales and Marketing

• Table 4-1: Key Contract Sales Organization Solutions to Maximize ROI
• Table 4-2: Global CSO Market, Revenues and Growth Rate, 2001-2011
• Table 4-3: CSO Revenues and Market Share by Leading Competitor 2005
• Table 4-4: Summary of inVentiv Health, Inc.’s Acquisitions