Stakeholder Opinions: Hematopoietic Stem Cell Transplantation - In need of further research and development

Published Date: April 2009 Published By: Datamonitor Page Count: 69 Order Code: R313-50617 $3,800.00   Online Download $9,500.00   Global Site License   Questions About This Report E-mail a Colleague Printable Page Fax Your Order Description Table of Contents Similar Products ABOUT DATAMONITOR HEALTHCARE About the Oncology pharmaceutical analysis team CHAPTER 1 EXECUTIVE SUMMARY Scope of analysis Datamonitor insight into hematopoietic stem cell transplantation Contributing experts Related reports Upcoming reports CHAPTER 2 HEMATOPOIETIC STEM CELL TRANSPLANTATION OVERVIEW Definition Overview of the hematopoietic stem cell transplantation procedure Use and applications of hematopoietic stem cell transplantation Types of stem cell transplants Stem cell donors Allogeneic transplants Autologous transplants Stem cell sources Bone marrow Peripheral blood Umbilical cord blood Conditioning Myeloablative conditioning Reduced-intensity conditioning (RIC) and nonmyeloablative conditioning Mortality and survival data CHAPTER 3 PHARMACOLOGIC USE Conditioning regimens Myeloablative regimens Reduced-intensity conditioning Conditioning by type of hematologic malignancy Research & development in the conditioning field Molecular targeted therapies Radioimmunotherapy Prophylaxis and treatment of hematopoietic stem cell transplantation complications Early complications Acute graft-versus-host disease (GVHD) Late complications Chronic graft-versus-host disease (GVHD) Secondary malignancies Other areas of research & development Augmentation of the graft-versus-tumor (GVT) effect Expansion of allogeneic HSCT to solid tumors CHAPTER 4 UNMET NEEDS & RESEARCH PRIORITIES Key findings Unmet needs and research priorities in hematopoietic stem cell transplantation HSCT remains an underutilized treatment Relapse remains the main cause of death after HSCT HSCT is in need of an overall refinement The effective management of graft-versus-host disease is considered a priority BIBLIOGRAPHY APPENDIX List of tables List of figures About Datamonitor About Datamonitor Healthcare About the Oncology analysis team Disclaimer List of Tables Table 1: Hematopoietic stem cell transplantation: definitions Table 2: Donor types for allogeneic hematopoietic stem cell transplantation Table 3: Comparison of stem cell sources for hematopoietic stem cell transplantation Table 4: Reduced-intensity conditioning (RIC) and nonmyeloablative regimens: mode of action Table 5: Three-year survival rates for patients with acute myeloid leukemia and diffuse large B-cell lymphoma Table 6: Examples of radiation-based conditioning regimens used in hematopoietic stem cell transplantation Table 7: Examples of chemotherapy-based conditioning regimens used in hematopoietic stem cell transplantation Table 8: Examples of reduced-intensity conditioning regimens used in hematopoietic stem cell transplantation Table 9: Examples of conditioning regimens used in hematopoietic stem cell transplantation by type of hematologic malignancy Table 10: Investigation of Rituxan and Campath in regimens used in hematopoietic stem cell transplantation conditioning Table 11: Investigation of anti-CD20 radioimmunotherapy in hematopoietic stem cell transplantation conditioning Table 12: Early complications of hematopoietic stem cell transplantation Table 13: Selected drugs available for use in the prophylaxis of acute graft-versus-host disease Table 14: Selected drugs investigated in the treatment of steroid-refractory acute graft-versus-host disease Table 15: Drugs/therapies in company-sponsored Phase III development for graft-versus-host disease as their primary indication, 2009 Table 16: Late complications of hematopoietic stem cell transplantation Table 17: Selected drugs investigated in the treatment of steroid-refractory chronic graft-versus-host disease List of Figures Figure 1: The normal hematopoiesis process Figure 2: Overview of the hematopoietic stem cell transplantation procedure Figure 3: The applications of autologous and allogeneic hematopoietic stem cell transplantation Figure 4: Main indications for hematopoietic stem cell transplantation in 2007, according to EBMT data Figure 5: Indications for allogeneic hematopoietic stem cell transplantation worldwide in 2005, according to CIBMTR data Figure 6: Annual number of hematopoietic stem cell transplantations worldwide, 1970-2006, according to CIBMTR data Figure 7: Stem cell sources for allogeneic and autologous transplants in patients over 20 years of age, 1997-2006, according to CIBMTR data Figure 8: The use of myeloablative and reduced-intensity conditioning regimens in allogeneic transplants, 1998-2006 according to CIBMTR data Figure 9: Age distribution of patients receiving allogeneic transplants by conditioning regimen intensity, 2005-06, according to CIBMTR data Figure 10: Causes of death after transplantations, 2001-06, according to CIBMTR data Figure 11: Unmet needs and research priorities in hematopoietic stem 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